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Drug Discovery and Development, Drug Development

Ekleyen: admin | Tarih: 8 Oca 2009 | Dahil Oldugu Kategoriler: İlaç Kimyası

From first principles to real-world applications-here is the first comprehensive guide to and

Modern and require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process.The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners.

Volume 1: describes all the steps in the process, including conceptualizing a , creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a as necessary.

Volume 2: delves into the nitty-gritty details of optimizing the synthetic route, manufacturing, outsourcing, and marketing-including coloring and delivery methods.

Featuring contributions from a world-class team of experts, and :

  • Features fascinating case studies, including the and of erythromycin analogs, Tagamet, and Ultiva (remifentanil)
  • Discusses the of medications for bacterial infections, Parkinson’s disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer
  • Includes chapters on combinatorial chemistry, molecular biology-based , genomics, and chemogenomics

and is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

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